ABSTRACT
An open non-comparative multicenter study of Itraconazole (Sporal) 400 mg as a single day therapy for vaginal candidosis was carried out at Siriraj Hospital and Chulalongkorn Hospital from 1st November 1988 to 31st August, 1989. Fifty-nine female out patients with vaginal candidosis were included in the study after excluding pregnancy, lactation, mixed vaginal infection and prior antimycotic therapy. Two capsules of 100 mg Itraconazole were given b.i.d. as a single day 400 mg dose. The patients were evaluated at the beginning prior to treatment for physical signs and symptoms, direct microscopic examination, and culture of vaginal fluid. The first and second follow-up were arranged at the end of one week and one month after therapy. The evaluations were the same as in the first visit. The clinical cure rate was 89 and 90 per cent at first and second follow-up respectively. The mycological cure rates were 83.3 and 69.57 per cent at the first and second follow-up respectively. There was one case of Torulopsis glabarta at the second follow-up.
Subject(s)
Acute Disease , Adolescent , Adult , Antifungal Agents/therapeutic use , Candidiasis, Vulvovaginal/drug therapy , Female , Humans , Itraconazole , Ketoconazole/analogs & derivatives , Middle AgedABSTRACT
Three isolates of satellite streptococci were cultivated from the blood of a patient affected persistent bacterial endocarditis. They had distinguishable ultrastructural abnormalities. Their cell wall architecture changed from a fuzzy coat (first isolate) to a thick electron transparent layer covered with a rough fuzzy coat (second isolate), and to electron dense globular material which detached from the wall in small patches (third isolate). The antibiotics probably played an important role in changing their architecture. These three isolates were probably derived from the same strain, since they had common biochemical characteristics and they were isolated from the same patient during the course of his endocarditis.
Subject(s)
Adult , Endocarditis, Bacterial/microbiology , Humans , Male , Staphylococcus aureus , Streptococcal Infections/microbiology , Streptococcus/classificationABSTRACT
A case report of chronic cholecystitis due to Enterobacter agglomerans, occurred in a 54-year old female with homozygous beta-thalassemia. The patient responded successfully to cholecystectomy and sulfamethoxazole + trimetroprim therapy. The source of the infection was not known, however, cystic duct obstruction and immune deficit were thought to be the predisposing causes.
Subject(s)
Cholecystectomy , Cholecystitis/complications , Cholelithiasis/complications , Combined Modality Therapy , Drug Therapy, Combination , Enterobacter/isolation & purification , Enterobacteriaceae/isolation & purification , Female , Humans , Middle Aged , Species Specificity , Sulfamethoxazole/therapeutic use , Thalassemia/complications , Trimethoprim/therapeutic useSubject(s)
Adult , Aspergillosis , Aspergillus fumigatus/isolation & purification , Endocarditis/microbiology , Female , HumansABSTRACT
Aeromonas sobria and A.hydrophila were isolated from infected fish in ratio of 3.5:1 during the outbreak of fish infections from December 1982 to February 1983, while isolates from human diarrheic stool was 1 :2. On the basis of IMVC reactions 138 isolates of motile aeromonads could be divided into 11 biogroups, with biogroup 4 showing statistically significant association with infections. Nine biogroups of aeromonads which were isolated from infected fish reflected that the outbreak was not caused by a single type of bacteria. There may have been some common factors which acted as predisposing causes. The possibility of zoonosis spreading of this epidemic infection of fish was low, because the majority of the infective agents in man and fish were different.